Volume 5, Issue 1, March 2020

Perspective

The Role of Pathologist in Precision Medicine
X. Frank Zhao
Abstract

Pathologists will play a key role in precision medicine for the follow reasons. Pathologists
have direct access to patient specimens, the most cutting-age diagnostic technologies, and integrated laboratory data to design therapeutic plans. Pathologists also have the upper hand in carrying out translational research utilizing patient specimens. Owing to these advantages, the pathologists will play an important part in future therapeutic target-based and individualized clinical trials, and their role will shift from that of a traditional diagnostician to that of a therapeutic consultant.

Case Study

Interdigitating Dendritic Cell Sarcoma with Aberrant EGFR Expression
Xianfeng Frank Zhao and Shiyong Li
Abstract

Diagnosis and treatment of interdigitating dendritic cell sarcoma (IDCS), a rare tumor of histiocytic origin, remain a challenge for both pathologists and hematologists/oncologists. Due to its rarity, there is no well-defined therapeutic regimen for this neoplasm. We report a case of IDCS with aberrant expression of epidermal growth factor receptor (EGFR) which was not detected in the normal follicular dendritic cells and interdigitating dendritic cells with immunohistochemistry. Molecular studies of the tumor showed no mutation in either the EGFR gene or KRAS gene. Our findings suggest that EGFR could be a novel diagnostic biomarker and therapeutic target for IDCS.