Volume 4, Issue 1, March 2019

Case Report

B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and mantle cell lymphoma
David Cantu, Raju Pillai, Suzanne Homan, Bharat Nathwani, and Dennis D. Weisenburger

The expression of cyclin D1 in diffuse large B-cell lymphomas has been reported in the literature several times. However, cases with the t(11;14)(q13;q32) are very uncommon. Herein, we present two cases of diffuse large B-cell lymphoma with the t(11;14)(q13;q32) and cyclin D1 expression, BCL6 rearrangement and BCL2 amplification, but negative for SOX11 expression. Although presence of the t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma, it can also be seen in diffuse large B-cell lymphoma, sometimes as a secondary aberration.