Hematopathology publishes pathological studies of blood diseases and covers more areas than any other pathology subspecialties; it also evaluates findings of autopsy, cytopathology, surgical pathology, neuropathology, and pediatric pathology. Laboratory studies, including transfusion medicine, hematology, coagulation, flow cytometry, cytogenetics, and molecular diagnostics, are also integral parts of Hematopathology.
The expression of cyclin D1 in diffuse large B-cell lymphomas has been reported in the literature several times. However, cases with the t(11;14)(q13;q32) are very uncommon. Herein, we present two cases of diffuse large B-cell lymphoma with the t(11;14)(q13;q32) and cyclin D1 expression, BCL6 rearrangement and BCL2 amplification, but negative for SOX11 expression. Although presence of the t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma, it can also be seen in diffuse large B-cell lymphoma, sometimes as a secondary aberration.