Volume 5, Issue 1, March 2020
Perspective
The Role of Pathologist in Precision Medicine | |
X. Frank Zhao | |
Abstract
Pathologists will play a key role in precision medicine for the follow reasons. Pathologists |
Case Study
Interdigitating Dendritic Cell Sarcoma with Aberrant EGFR Expression | |
Xianfeng Frank Zhao and Shiyong Li | |
Abstract Diagnosis and treatment of interdigitating dendritic cell sarcoma (IDCS), a rare tumor of histiocytic origin, remain a challenge for both pathologists and hematologists/oncologists. Due to its rarity, there is no well-defined therapeutic regimen for this neoplasm. We report a case of IDCS with aberrant expression of epidermal growth factor receptor (EGFR) which was not detected in the normal follicular dendritic cells and interdigitating dendritic cells with immunohistochemistry. Molecular studies of the tumor showed no mutation in either the EGFR gene or KRAS gene. Our findings suggest that EGFR could be a novel diagnostic biomarker and therapeutic target for IDCS. |