Volume 3, Issue 2, September 2018


Precision Pathology: A New Frontier
X. Frank Zhao


The Role of Pathology in Precision Medicine
Maher Albitar

In the era of precision medicine, complex disease-specific and host-specific metrics are becoming essential and must be implemented in patients care. Because of cancer heterogeneity, precision medicine is more impactful in oncology than any other field. However, it is becoming increasingly difficult to keep up with the vast knowledge and fast pace of advances in cancer management and therapy. For that current cancer care requires multidisciplinary team approach. Pathologists are very important component of this team and their role is expanding significantly. Pathologists must not only provide the morphologic diagnosis, but they are required to provide information on the biological and molecular characteristics of the disease and the host. They must present and discuss the clinical relevance of the various molecular and biological findings in selecting therapy, predicting prognosis and planning the course of management. This article discusses the changing role of pathologists in the era of precision medicine and the importance of more engagement of pathologists in the daily clinical decisions and patient care.

Case Report

Central Nervous System Myelomatosis in the Era of Precision Medicine
Neda Wick and Mingyi Chen

Multiple myeloma (MM) is a diverse clonal plasma cell malignancy with resultant organ
damage including renal and bone marrow effects, as well as neurologic and immune dysfunction. MM is characterized as clinically and pathologically heterogeneous with significant variability in treatment response and survival. The genetically high-risk myeloma is often manifested as clinical relapsed and refractory disease. In this article, we summarize the most recent progress of molecular diagnosis and targeted treatment of multiple myeloma. We review the landscape of chromosomal abnormalities in myeloma and discuss the clinical impact on patient outcomes. We also present case report of a rare myeloma complication: central nervous system (CNS) myelomatosis. This study will help to understand the biology of CNS myeloma and its therapeutic implications in the era of precision medicine.


Extramedullary hematopoiesis manifesting as pleural effusion in a patient with post-polycythemic myelofibrosis
Karen Zeigler and Yi Xie