In the era of precision medicine, complex disease-specific and host-specific metrics are becoming essential and must be implemented in patients care. Because of cancer heterogeneity, precision medicine is more impactful in oncology than any other field. However, it is becoming increasingly difficult to keep up with the vast knowledge and fast pace of advances in cancer management and therapy. For that current cancer care requires multidisciplinary team approach. Pathologists are very important component of this team and their role is expanding significantly. Pathologists must not only provide the morphologic diagnosis, but they are required to provide information on the biological and molecular characteristics of the disease and the host. They must present and discuss the clinical relevance of the various molecular and biological findings in selecting therapy, predicting prognosis and planning the course of management. This article discusses the changing role of pathologists in the era of precision medicine and the importance of more engagement of pathologists in the daily clinical decisions and patient care.