Tag: 2019-V4I1

Diagnosis of classic Hodgkin lymphoma (CHL) is quite straightforward with the integrated
clinical, morphological, and immunophenotypic studies. Due to the variation in morphology and immunophenotype, CHL diagnosis remains a challenge. Based on their many years of experience in diagnostic practice, the authors summarized eleven uncommon variants of CHL: 1) CHL with xanthogranulomatous inflammation, foamy histiocytes and loose granulation tissue-like stroma; 2) epithelioid cell-rich and granulomatous CHL; 3) CHL with prominent keloid-like fibrosis; 4) CHL rich in plump histiocytes arranging in a fascicular pattern; 5) intrasinusoidal CHL; 6) interfollicular CHL: 7) neutrophil-rich CHL; 8) neoplastic cell-rich CHL; 9) lymphocyte depleted CHL; 10) CHL with aberrant immunophenotypes; 11) grey-zone CHL. These variants pose diagnostic pitfalls to the practicing pathologists.

The expression of cyclin D1 in diffuse large B-cell lymphomas has been reported in the literature several times. However, cases with the t(11;14)(q13;q32) are very uncommon. Herein, we present two cases of diffuse large B-cell lymphoma with the t(11;14)(q13;q32) and cyclin D1 expression, BCL6 rearrangement and BCL2 amplification, but negative for SOX11 expression. Although presence of the t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma, it can also be seen in diffuse large B-cell lymphoma, sometimes as a secondary aberration.