Volume 4, Issue 1, March 2019


The Uncommon Faces of Classic Hodgkin Lymphoma
Stefano Fratoni and Pasquale Niscola

Diagnosis of classic Hodgkin lymphoma (CHL) is quite straightforward with the integrated
clinical, morphological, and immunophenotypic studies. Due to the variation in morphology and immunophenotype, CHL diagnosis remains a challenge. Based on their many years of experience in diagnostic practice, the authors summarized eleven uncommon variants of CHL: 1) CHL with xanthogranulomatous inflammation, foamy histiocytes and loose granulation tissue-like stroma; 2) epithelioid cell-rich and granulomatous CHL; 3) CHL with prominent keloid-like fibrosis; 4) CHL rich in plump histiocytes arranging in a fascicular pattern; 5) intrasinusoidal CHL; 6) interfollicular CHL: 7) neutrophil-rich CHL; 8) neoplastic cell-rich CHL; 9) lymphocyte depleted CHL; 10) CHL with aberrant immunophenotypes; 11) grey-zone CHL. These variants pose diagnostic pitfalls to the practicing pathologists.

Case Report

B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and mantle cell lymphoma
David Cantu, Raju Pillai, Suzanne Homan, Bharat Nathwani, and Dennis D. Weisenburger

The expression of cyclin D1 in diffuse large B-cell lymphomas has been reported in the literature several times. However, cases with the t(11;14)(q13;q32) are very uncommon. Herein, we present two cases of diffuse large B-cell lymphoma with the t(11;14)(q13;q32) and cyclin D1 expression, BCL6 rearrangement and BCL2 amplification, but negative for SOX11 expression. Although presence of the t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma, it can also be seen in diffuse large B-cell lymphoma, sometimes as a secondary aberration.