Volume 5, Issue 1, March 2020


The Role of Pathologist in Precision Medicine
X. Frank Zhao

Pathologists will play a key role in precision medicine for the follow reasons. Pathologists
have direct access to patient specimens, the most cutting-age diagnostic technologies, and integrated laboratory data to design therapeutic plans. Pathologists also have the upper hand in carrying out translational research utilizing patient specimens. Owing to these advantages, the pathologists will play an important part in future therapeutic target-based and individualized clinical trials, and their role will shift from that of a traditional diagnostician to that of a therapeutic consultant.

Case Study

Interdigitating Dendritic Cell Sarcoma with Aberrant EGFR Expression
Xianfeng Frank Zhao and Shiyong Li

Diagnosis and treatment of interdigitating dendritic cell sarcoma (IDCS), a rare tumor of histiocytic origin, remain a challenge for both pathologists and hematologists/oncologists. Due to its rarity, there is no well-defined therapeutic regimen for this neoplasm. We report a case of IDCS with aberrant expression of epidermal growth factor receptor (EGFR) which was not detected in the normal follicular dendritic cells and interdigitating dendritic cells with immunohistochemistry. Molecular studies of the tumor showed no mutation in either the EGFR gene or KRAS gene. Our findings suggest that EGFR could be a novel diagnostic biomarker and therapeutic target for IDCS.

Case Study

Epstein-Barr virus-associated transformation of primary cutaneous follicle center lymphoma to diffuse large B-cell lymphoma, a case and review of the literature
Amalie Alver and Neil G. Haycocks

Primary cutaneous follicle center lymphoma (PCFCL) is a rare, indolent neoplasm with a good prognosis. Transformations of PCFCL into more aggressive non-Hodgkin lymphomas, such as diffuse large B-cell lymphoma (DLBCL), are extremely uncommon, with few cases reported in the literature. We present a case report of an 84-year-old man with a history of PCFCL who presented 26 months after initial treatment with an enlarged lymph node in the right neck. Excisional biopsy revealed DLBCL. Further studies showed the presence of Epstein-Barr virus (EBV), and molecular studies were consistent with the two neoplasms being clonally related. Taken together, these findings suggest an EBV-driven transformation of PCFCL to DLBCL in this patient.